Maestro Media has announced the latest Four Souls challenge, Delirious via tweet today. To access the PDF, visit Maestro Media and scroll down past the news section for a direct download link.
The preface reads:
For Isaac, the divide between sanity and madness grows tenuously thin; a ceaseless delirium ever closer. Can you guide your characters to overcome that most intangible of adversaries, even as the lines between past, present, and future blur? After all, the hardest enemy of all is your own mind…
Additionally, this challenge is available on the official Tabletop Simulator, just load up The Binding of Isaac: Four Souls Requiem+ and select Challenges from the starting game options.