First Edition
| Card Name | The Mark |
| Type | Treasure Deck |
| Card Text | You have 5+ andcan be attacked. On your turn, other players have 5+ andcan be attacked. +1  |
| Category | Passive Items |
| Game Mode(s) | Group (3+ Players)  |
| Set | The Unboxing of Isaac  |
| Released | 2022 |
| Language(s) | English |
| Background Artist | Yazawa Akio |
| Card Artist | HamBerry |
The Mark, along with Satanic Bible and The Nail, was exclusive to The Unboxing of Isaac subscription service for October 2022 (The Bloat!!!! Box).