First Edition
| Card Name | The Adversary |
| Type | Monster Deck |
| Card Text |  4
|  4+
|  1At the start of each turn, The active player rolls- monster slot into discard. 3-4: Put the top card of the monster deck in another monster slot. 5-6: Monsers gain +1  tillend of turn.  +1 Treasure  |
| Category | Bosses |
| Game Mode(s) | All Game Modes |
| Set | The Unboxing of Isaac  |
| Released | 2022 |
| Language(s) | English |
| Background Artist | Yazawa Akio |
| Card Artist | Yazawa Akio |
The Adversary, along with Big Horn and Loki, was exclusive to The Unboxing of Isaac subscription service for December 2022 (Isaac is Doomed! Box).
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