First Edition
| Card Name | Big Horn |
| Type | Monster Deck |
| Card Text |  6
|  3+
|  1At the start of each turn or each time this deals combat damage, the active player deals 1 damage to a player chosen at random.  +1 Treasure  |
| Category | Bosses |
| Game Mode(s) | All Game Modes |
| Set | The Unboxing of Isaac  |
| Released | 2022 |
| Language(s) | English |
| Background Artist | Yazawa Akio |
| Card Artist | Yazawa Akio |
Big Horn, along with Loki and The Adversary, was exclusive to The Unboxing of Isaac subscription service for December 2022 (Isaac is Doomed! Box).
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