First Edition
| Card Name | Cain |
| Type | Characters |
| Card Text |  2 |  1 Play an additionalloot card this turn. This can be done on any player’s
turn in response to any action. Starting Item: Sleight of Hand |
| Starting Item |  |
| Game Mode(s) | All Game Modes |
| Set | The Unboxing of Isaac  |
| Released | 2023 |
| Language(s) | English |
| Card Artist | Edmund McMillen |
Cain, along with Isaac and The Lost, was a free, exclusive bonus for those who purchased an entire year of The Unboxing of Isaac subscription service. The 13th box was given to both annual and monthly subscribers, as long as no boxes were skipped.
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