First Edition
| Card Name | 1-Up |
| Type | Treasure Deck |
| Card Text | If you would die during your turn, destroy this, prevent death, heal to full  , and cancel yourattack if able. You may attack an additional time this turn. |
| Category | Passive Items |
| Game Mode(s) | All Game Modes |
| Set | Promos  |
| Released | 2022 |
| Language(s) | English, French, German, Italian, Spanish |
| Card Artist | Matt Kap |
1-Up and Eden were included in the deluxe console release of The Binding of Isaac: Repentance, Leviathan Box, released in limited quantities in 2022. These cards were designed and printed before the conception of the second edition, so despite being released later, they do not have cohesive wording and formatting with the later version.