Second EditionFirst Edition
| Card Name | Isaac! |
| Type | Monster Deck |
| Card Text |  7
|  3+
|  1Each time this takes damage, the active player chooses a living player. This deals 1 damage to that player.  +1 Treasure  |
| Category | Epic Bosses |
| Game Mode(s) | Group (3+ Players)  |
| Set | Expansion: Four Souls+  |
| Released | 2022 |
| Language(s) | English, French, German, Italian, Spanish |
| Background Artist | Yazawa Akio |
| Card Artist | Rojen241 |
| Card Name | Isaac! |
| Type | Monster Deck |
| Card Text | 7
| 3+
| 1 Each time this takes damage from an attack, deal 1 damage to a player of your choosing. +1 Treasure |
| Category | Epic Bosses |
| Game Mode(s) | Group (3+ Players) |
| Set | Expansion: Four Souls+  |
| Released | 2019 |
| Language(s) | English |
| Background Artist | TikaratheMew |
| Card Artist | Rojen241 |
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