The Binding of Isaac: Four Souls

A complete reference for The Binding of Isaac: Four Souls card game.

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- Bonus Souls
- Characters
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- Starting Items
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Starting Items

Guppy’s Head (Nendoroid)

Ball of Tar

Club

Unstable DNA

Bag-O-Trash

Classic Roller

The Real Left Hand

Is You

Possession

Football

Strange Marble

Emergency Meeting

Polar Star / Booster V2.0

Bow and Arrow

Rusty Spoons

Johnny’s Knives

Hunky Boys

Girlfriend

Lollypop

Pop Pop!

Focus

Gravity

Ring of the Snake

Spelunking Pack

Anima Sola / The Revenant

Lemegeton

Abyss

Hemoptysis

Keeper’s Bargain

Soulbond

Glitch

Dead Weight

Flip

IBS

Gello

Sumptorium

Beserk

Ceremonial Blade

Hypercoagulation

Bag of Crafting

Spindown Dice

Sibling Rivalry

Book of Virtues

Dark Arts

Gimpy

Bag-o-Trash

Void

Lord of the Pit

Wooden Nickel

Holy Mantle

Lazarus’ Rags

The Curse

Blood Lust

Yum Heart

The D6

Pink Proglottid

Sleight of Hand

Incubus

Forever Alone

The Bone

Infestation

Ball of Tumors

Lil Steven

Book of Belial

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Latest Updates

G FUEL Promo Cards!
The Binding of Isaac is collaborating with G FUEL to release an exclusive collector’s box which will include two limited-edition… Continue reading G FUEL Promo Cards!
Trick or Treat Challenge
Maestro Media has announced the latest Four Souls challenge, Trick or Treat via tweet today. To access the PDF, visit Maestro… Continue reading Trick or Treat Challenge
Lord of the Flies Challenge
Maestro Media has announced the latest Four Souls challenge, Lord of the Flies, via tweet today. To access the PDF,… Continue reading Lord of the Flies Challenge

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The Binding of Isaac: Four Souls is ™ & © 2025 Edmund McMillen and Maestro Media