The Binding of Isaac: Four Souls

A complete reference for The Binding of Isaac: Four Souls card game.

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Curses

Curse of Envy

Curse of the Soulless

Curse of the Hunted

Curse of the Hollow

Curse of Empathy

Curse of the Suspicious

Curse of Blood Lust

Curse of Impulse

Curse of Fatigue

Curse of Tiny Hands

Curse of the Blind

Curse of Pain

Curse of Loss

Curse of Greed

Curse of Amnesia

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Latest Updates

G FUEL Promo Cards!
The Binding of Isaac is collaborating with G FUEL to release an exclusive collector’s box which will include two limited-edition… Continue reading G FUEL Promo Cards!
Trick or Treat Challenge
Maestro Media has announced the latest Four Souls challenge, Trick or Treat via tweet today. To access the PDF, visit Maestro… Continue reading Trick or Treat Challenge
Lord of the Flies Challenge
Maestro Media has announced the latest Four Souls challenge, Lord of the Flies, via tweet today. To access the PDF,… Continue reading Lord of the Flies Challenge

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The Binding of Isaac: Four Souls is ™ & © 2025 Edmund McMillen and Maestro Media